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LAWRENCE C. CREEMER, MS

SCIENTIFIC AND TECHNICAL CONSULTANT

1763 North James Blvd, Greenfield, IN 46140

317.498.5149

lccreemer@gmail.com

http://www.linkedin.com/in/lawrence-creemer-MS

Curriculum Vitae

Research | Team Leadership | Collaboration | Investigation

Applying knowledge, experience, and ideation for discovery and early development in organic and medicinal chemistry, natural products chemistry, structure activity relationships (SAR), application technology, and formulations for agrochemicals, animal health drugs, and pharmaceuticals. Utilize expertise to help technical entities develop and expand ideas and evaluate ideas and opportunities available from others.

PROFESSIONAL PROFILE

  • Thirty+ years of experience as an industrial life sciences R&D researcher scientist and team leader working in Discovery and Early Development as well as evaluation of external technology and collaboration leader.

  • Expert in macrolide and natural products chemistry

  • Regulatory Chemistry Leader for GLP Analytical and Reference samples for most of Corteva’s commercial Crop Protection portfolio.

  • Regulatory Chemistry Team Leader for 2 novel plant antifungal compounds in Regulatory Submission Review with projected annual sales of $500M+.

  • Principle Investigator with 16 granted patents for CNS pharmaceuticals, animal health macrolide antibiotics, immune-potentiators, and agrochemicals, including co-invention of the insecticide Spinetoram with annual sales of $300M+ million.

  • Co-author of 23 peer-reviewed articles and book chapters, presenter of 22 symposia presentations (please see addendum), and co-author of several internal reports and presentations.

  • Group and Team Leader for inter-disciplinary projects covering Discovery and Early Development Chemistry through regulatory submission in the areas of small molecule agrochemicals, animal health and pharmaceuticals.

  • External Technology Manager and collaboration leader for several projects working with university professors, small start-up companies and large multi-national companies.

EDUCATION

Master of Science (MS), Organic Chemistry, Purdue University, Indianapolis, IN

Bachelor of Science (BS), Chemistry, Michigan Technological University, Houghton, MI

FURTHER EDUCATION

  • Radiation Safety and 14C-Synthesis Training

  • Batch Process Scale-Up and Chemical Engineering for Chemists Training

  • Molecular Biology Training (I.U. School of Medicine)

  • Advanced Organic Synthesis Courses and Experimental Design Training

  • Molecular Modeling for Small Organic Compounds Training

  • SciFinder and other Advanced Data Searching Tools Training

  • Interpersonal skills

  • Six Sigma Greenbelt Training

  • Achieving Value Through Partnership

  • Four Disciplines of Execution

  • Franklin-Covey 7 Habits of Highly Effective People

  • 360 degree Leadership Training

  • Strengths Finder 2.0

PROFESSIONAL EXPERIENCE

CORTEVA AGRISCIENCE, Indianapolis, IN 2019 - 2020

Principle Investigator, Regulatory Chemistry

Handled production of all analytical and reference GLP standards for 100+ commercial products.

  • Organized efficient and timely ordering and synthesis of Analytical and Reference Standards necessary for release of production lots for all organization’s commercial products across several sites and production facilities.

  • Developed database, enabling collection and containment of all synthesis information on company’s Reference and Analytical standards, including those from DuPont Agrichemicals after loss of personnel during merger.

Technology Acquisition and Alliance Manager

Continued role after merger between Corteva and Dow. Located and performed technical review, evaluation, and collaboration of potential third-party technology for acquisition of seed treatments, process chemistry, application technologies, and formulations.

  • Led collaboration of multi-disciplinary teams for several opportunity candidates, leading to either advancement or conclusion.

  • Developed new tools, including a phone application, boosting efficiency and involvement of the entire R&D staff in scouting out new potential acquisition opportunities.

DOW AGROSCIENCES, LLC. (Merged to form Corteva in 2019), Indianapolis, IN 2009 - 2019

Technology Acquisition and Alliance Manager 2018 - 2019

Senior Research Scientist 2013 - 2019

Process Chemistry Metabolites and Radiotracers

  • Led regulatory chemistry efforts for 2 plant antifungal compounds in Regulatory submission, including synthesis of 14C radio tracers and subsequent identification and synthesis of resulting metabolites for regulatory submission studies of several developmental candidates.

  • Aided in timely submission of the regulatory dossier with a combined commercial potential of $700M+ through identification and synthesis of several unknown metabolites for 2 new plant antifungal compounds in advanced development.

  • Protected $400M+ in sales by designing and synthesizing C14 analogs necessary for reregistration of several commercial compounds.

Lead Research Specialist, Discovery Chemistry Research 2009 - 2013

  • Discovered and advanced candidate molecules through SAR.

  • Led team to advance SAR of a lead aphicide molecule and showed further development was not appropriate, saving time and several million dollars in development costs.

  • Introduced a new system for active candidate discovery base on protein homology, leading to a systematic method to mine Pharma literature for potential new agrochemical leads.

ELI LILLY AND COMPANY, ELANCO ANIMAL HEALTH 2003 - 2009

Senior Research Scientist Food Animal Therapeutics API Development 2006 - 2009

  • Led Development Team of a new animal health antibiotic.

  • Worked as Project Manager, facilitating development of a new animal health antibiotic with a sales potential of $250M+ per year.

  • Served as development chemistry leader for a new animal health antibiotic, advancing chemistry to the first kilogram through collaboration with a partner lab.

Research Scientist, Group Leader Synthesis and Process Chemistry 2004 - 2006

  • Headed group of 2 senior and 1 associate chemist responsible for all organic / medicinal chemistry needs.

  • Expanded Synthesis and Process Chemistry group by recruiting and supervising both a senior and associate scientist.

  • Worked on design team, overseeing construction of a new organic bench and kilo lab.

Senior Organic Chemist, Group Leader: Elanco Synthesis and Process Chemistry 2003 - 2004

  • Served as sole organic chemist for all Elanco development projects.

  • Created a new group responsible for all organic chemistry for development of new animal health compounds.

PATENTS

“Process for the preparation of certain triaryl rhamnose carbamates” L.C.Creemer, C.DeAmicis, G.D.Crouse, P.Borromeo: US Pat#9,193,750 Issued 11/25/15

“Pesticidal compositions and processes related thereto” G.D.Crouse, T.C.Sparks, W.H.Dent III, C.L.McLeod, L.C.Creemer, D.A.Demeter, A.E.Fritz, L.G.Fischer, E.W.Baum: US Pat #9107413 Issued 8/18/15

“Pesticidal Compositions and Processes Related Thereto” G.D.Crouse, T.C.Sparks, W.H.Dent III, C.L.McLeod, L.C.Creemer, D.A.Demeter, A.E.Fritz, L.G.Fischer, E.W.Baum: US Pat #9,018,136 B2 Issued 4/28/15

“Pesticidal Compositions and Processes Related Thereto” E.W.Baum, G.D.Crouse, W.H.Dent III, T.C.Sparks, L.C.Creemer: US Pat #9,018,300 B2 Issued 4/28/15

“Pesticidal Compositions and Processes Related Thereto” G.D.Crouse, T.C.Sparks, W.H.Dent III, C.L.McLeod, L.C.Creemer, D.A.Demeter, A.E.Fritz, L.G.Fischer, E.W.Baum: US Pat #8,815,922 B2 Issued 8/26/14

“Pesticidal Compositions” L.C.Creemer, G.D.Crouse, T.C.Sparks, C.L.McCloed: US Pat #8,551,914 B2 Issued 10/8/13

“Immunopotentiator Agents” E.D.McGruder, L.C.Creemer, J.R.Herring: US Pat #6,664,271 Issued 12/16/03

“Synthetic Modification of Spinosyn Compounds”, C.S.DeAmicis, P.B.Anzeveno, J.G.Martynow, K.L.McLaren, F.R.Green III, T.C.Sparks, H.A.Kirst, L.C.Creemer, T.V.Worden, J.R.Schoonover Jr, J.M.Gifford, C.J.Hatton, V.B.Hegde, G.D.Crouse, B.R.Thoreen, M.J.Ricks: US Pat #6,001,981 Issued 12/14/99.

*Please see attached ADDENDUM for additional Patents

PUBLICATIONS AND BOOK CHAPTERS

“Pro-insecticidal Approach Towards Increasing in plant Activity”, L.C.Creemer, N.C.Giampietro, W.Lambert, M.C.Yap, G.J.deBoer, Y.Adelfinskaya, S.Castetter, F.J.Wessels, Pest Manag Sci, 73(4), 752-760, 2017.

“NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry”, N.R.Babij, E.O.McCusker, G.T.Whiteker, B.Canturk, L.C.Creemer, N.Choy, C.V.De Amicis, N.M.Hewlett, P.L.Johnson, J.Knobelsdorf, F.Li, B.A.Lorsbach, B.M.Nugent, S.J.Ryan, M.R. Smith, Q.Yang, Org. Proc. Res. Dev. 20 (3), 661-667, 2016.

“Production and Characterization of Monoclonal Antibodies against the Antibiotic Tilmicosin”, R.C.Beirer, L.C.Creemer, R.L.Ziprin, and D.J.Nisbet, J. Agri. Food Chem.,53, 9679-9688, 2005.

“Development of an Efficient Synthesis for a Nipecotate-Containing Immunopotentiator”, E.D. Moher, A.E. Tripp, L.C. Creemer, and J.T. Vicenzi, Org. Proc. Res. And Dev, 8, 593-596, 2004.

“Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates”, L.C.Creemer, R.C.Beier, D.E.Kiehl, J. Antibiotics, 56 (5), 481-487, 2003.

“Synthesis and In Vitro Antimicrobial Activity of 3-Keto 16-Membered Macrolides Derived From Tylosin”, L.C.Creemer*, J.E.Toth, H.A.Kirst, J. Antibiotics, 55 (4), 427-436, 2002.

“The Stereochemical Outcome of Electrophilic Addition Reactions on the 5,6-Double Bond in the Spinosyns”, C.V.DeAmicis, P.R.Graupner, J.A.Erickson, J.W.Paschal, H.A.Kirst, L.C.Creemer, P.E.Fanwick, J. Org. Chem., 66 (25), 8431, 2001.

“Synthesis and Insecticidal Activity of Spinosyn Analogs Functionally Altered at the 2’-,3’- and 4’-Positions of the Rhamnose Moiety”, L.C.Creemer*, H.A.Kirst, J.W.Paschal, T.V.Worden, J. Antibiotics, 53 (2), 171, 2000.

“Conversion of Spinosyn A and Spinosyn D to Their Respective 9- and 17-Pseudoaglycones and Their Aglycones”, L.C.Creemer*, H.A.Kirst, J.W.Paschal, J. Antibiotics, 51 (8), 795, 1998.

“Evaluation and Development of Spinosyns to Control Ectoparasites on Cattle and Sheep”, H.A.Kirst, L.C.Creemer, S.A.Naylor, P.T.Pugh, D.E.Snyder, J.R.Winkle, T.C.Sparks, T.V.Worden, L.B.Lowe, J.T.Rothwell, Curr. Top. Med. Chem. 2, 675-699, 2002.

“Chemical and Microbial Modifications of Spinosyn: Exploring Synergies Between Fermentation Microbiology and Organic Chemistry”, H.A.Kirst, L.C.Creemer, M.C.Broughton, M.L.B.Huber, J.R.Turner, Synthesis and Chemistry of Agrochemicals VI, Chapter 24, pgs 251-261, Don R. Baker, Joseph G. Fenyes, Thomas P. Selby, Thomas M. Stevenson, Ed., ACS publications 2002.

“Chemistry and Insecticidal Activity of the Spinosyns”, G.D.Crouse, T.C.Sparks, C.V.DeAmicis, H.A.Kirst, J.G.Martynow, L.C.Creemer, T.V.Worden, P.A.Anzeveno, Pesticide Chemistry and Bioscience; The Food-Environment Challenge, Ed. Gerald T. Brooks and Terry R. Roberts, The Royal Society of Chemistry, 1998.

“Chemistry and Biology of the Spinosyns: Components of Spinosad (Tracer), The First Entry into DowElanco’s Naturalyte Class of Insect Control Products”, T.C.Sparks*, H.A.Kirst, J.S.Mynderse, G.D.Thompson, J.R.Turner, O.K.Jantz, M.B.Hertlein, L.L.Larson, P.Baker, M.C.Broughton, J.D.Busacca, L.C.Creemer, M.L.Huber, J.W.Martin, W.Nakatsukasa, J.W.Paschal, T.V.Worden, 1996 Proc. Beltwide Cotton Production Conf., Nashville, Tennessee, January 9-12, page 692, National Cotton Council of America, 1996

“Determination of the Inherent Antimicrobial Activity of Dirithromycin by Measuring Cell-Free Inhibition of Protein Synthesis”, H.A.Kirst*, L.C.Creemer, D.A.Preston, W.E.Alborn Jr., New Macrolides, Azalides and Streptogramins in Clinical Practice, H.C.Neu, L.S.Young, S.H.Zinner, and J.Acar, eds., Marcel Dekker Inc., New York, 1995, pp.187-190.

*Please see attached ADDENDUM for additional Publications

PRESENTATIONS

“In Pursuit of Inatreq Active’s Unstable Metabolite: M14” L. Creemer, M. Ma, Y. Adelfinskaya, A. Shoulds, P. Graupner, P. Johnson, W. Dent, R. Ross, 256th ACS National Meeting & Exposition, Virtual Meeting, United States, August 17-20, 2020, Abstract #AGRO-204

“Preparation of Fenpicoxamid Standards to Support Registration Studies”. P.Johnson, L.Creemer, K.G.Meyer, R.Ross, 256th ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2018, Abstract #AGRO-212

“Pro-Insecticidal Approach Towards Increasing In Planta Activity”, L.C.Creemer, N.C.Giampietro, F.Wessels, W.Lambert, M.Yap, G.DeBoer, Y.Adelfinskaya, 250th ACS National Meeting, Boston, MA, U.S.A., August 16-20, Abstract (Agrochemical Division) #338.

“Leveraging mammalian therapeutic research to identify novel Lead chemistries for crop protection”, L.C.Creemer, J.E.Hunter, M.Loso, F.E.Tisdell, M.C.Yap, 248th ACS National Meeting, San Fransico, CA, U.S.A., August 10-14, Abstract (Agrochemical Division) #44

“Hapten Synthesis, Conjugation, and the Production of Monoclonal Antibodies to the Macrolide Antibiotic Tilmicosin”, R.C.Beier, L.C.Creemer, sixth International Conference on Agri-Food Antiboidies, Prague, Czech Republic, October 2-5, 2001.

“Exploring Structural Modifications and Structure-Activity Relationships of the Spinosyns”, H. A. Kirst, L.C.Creemer, seventh Internation Conference on Chemistry of Antibiotics and Related Microbial Products, Mierki, Poland, September 2-6, 2000, Abstract #IL-2.

“Chemical and Microbial Modification of Spinosyn, Exploring the Synergies between Fermentation Microbiology and Organic Chemistry”, H.A.Kirst, L.C.Creemer, M.C.Broughton, M.L.B.Huber, J.R.Turner, 217th National ACS Conference, Anaheim, California, March 21-25, 1999, Abstract (Agrochemical Division) #40.

Please see attached ADDENDUM for additional Presentations

ADDENDUM

FURTHER PATENTS

“New A83543 Compounds and Process for Production Thereof”, J.S.Mynderse, J.A.Mabe, J.R.Turner, M.L.B.Huber, M.C.Broughton, W.M.Nakatsukasa, L.C.Creemer, , H.A.Kirst, J.W.Martin; US Pat #5,670,486 Issued 9/23/97.

“New A83543 Compounds and Process for Production Thereof”, J.S.Mynderse, J.A.Mabe, J.R.Turner, M.L.B.Huber, M.C.Broughton, W.M.Nakatsukasa, L.C.Creemer, , H.A.Kirst, J.W.Martin; US Pat #5,670,364 Issued 9/23/97.

“A83543 Aglycones and Pseudoaglycones”, M.C.Broughton, L.C.Creemer, M.L.B.Huber, H.A.Kirst, J.R.Turner; US Pat #5,539,089 Issued 7/13/96.

“Stereochemical Wortmannin Derivatives”, L.C.Creemer, H.A.Kirst; US Pat #5,480,906 Issued 1/2/96.

“New A83543 Compounds and Processes for Production Thereof”, M.C.Broughton, L.C.Creemer, M.L.B.Huber, H.A.Kirst, J.W.Martin, J.S.Mynderse, J.R.Turner; US Pat #5,202,242 Issued 4/13/93.

"Novel Aminoalkyl-Substituted Heterocyclic Sulfur Compounds", T.M.Bargar, R.J.Broersma, L.C.Creemer; US Pat #4,894,389 Issued 1/16/90.

"Preparation of Novel Aminoalkyl-Substituted Dithiolane and Thiophene Compounds as Antihypertensive Agents", T.M.Bargar, L.C.Creemer, R.J.Broersma; US Pat #4,970,228 Issued 11/13/90

"Preparation and Formulation of Heterocyclyl-2-propyn-1-amines as Antihypertensives", T.M.Bargar, L.C.Creemer, J.R.McCarthy;US Pat #4,743,617 Issued 5/10/88.

FURTHER PUBLICATIONS AND BOOK CHAPTERS

“Synthesis and In Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase”, L.C.Creemer*, H.A.Kirst, C.J.Vlahos, R.M.Schultz, J. Med. Chem., 39 (25), 5021, 1996.

“Structure of the New Spiroketal-Macrolide A82548A”, H.A.Kirst*, S.H.Larsen, J.W.Paschal, J.L.Occolowitz, L.C.Creemer, J.L.Rios Steiner, E.Lobkovsky, J.Clardy, J. Antibiot., 48 (9), 990, 1995.

“Antimicrobial Characterization and Interrelationships of Dirithromycin and Epidirithromycin”, H.A.Kirst*, L.C.Creemer, J.W.Paschal, D.A.Preston, W.E.Alborn Jr., F.T.Counter, J.B.Amos, R.L.Clemens, K.A.Sullivan, J.M.Greene, Antimicro. Agents Chemother., 39 (7), 1436, 1995.

“Synthesis, Antimicrobial Activity and In Vivo Fluorine NMR of a Hexafluorinated Derivative of Tilmicosin”, L.C.Creemer*, H.A.Kirst, T.R.Shryock, J.B.Campbell, A.G.Webb, J. Antibiot., 48 (7), 671, 1995.

“Identification and Synthesis of Products Isolated During Metabolism Studies of Tilmicosin”, H.A.Kirst*, A.L.Donoho, L.C.Creemer, J.A.Wind, D.M.Berry, J.L.Occolowitz, J.W.Paschal, J. Agric. Food Chem. 42, 1219, 1994.

"A83543A-D, Unique Fermentation-Derived Tetracyclic Macrolides", H.A.Kirst*, K.H.Michel, J.W.Martin, L.C.Creemer, E.H.Chio, R.C.Yao, W.M.Nakatsukasa,

L.D.Boeck, J.L.Occolowitz, J.W.Paschal, J.B.Deeter, N.D.Jones, G.D.Thompson, Tetrahedron Lett., 32 (37), 4839, 1991.

"Highly Effective Mechanism-Based Inactivation of Dopamine-Hydroxylase by a Novel Ketene Thio-acetal", T.M.Bargar*, R.J.Broersma, L.C.Creemer, J.R.McCarthy, J.M.Hornsperger, P.V.Attwood, M.J.Jung, J. Am. Chem. Soc., 110, 2975, 1988.

"A Convenient Synthesis of -Bis(alkylthio)-acrylonitriles", L.C.Creemer*, T.M.Bargar, E.R.Wagner, Syn. Commun., 18 (10), 1103, 1988.

"Unsaturated Heterocyclic Amines as Potent Time-Dependent Inhibitors of Dopamine--Hydroxylase”, T.M.Bargar*, R.J.Broersma, L.C.Creemer, J.R.McCarthy, J.M.Hornsperger, M.G.Palfreyman, J.Wagner, M.J.Jung, J. Med. Chem., 29, 315, 1986.

FURTHER PRESENTATIONS

“Synsthesis and In Vitro Antimicrobial Activity of 3-Keto 16-Membered Macrolides Derived From Tylosin”, L.C.Creemer, H.A.Kirst, J.E.Toth, 213th National ACS Conference, San Francisco, California, April 13-17, 1997, Abstract (Medicinal Chemisry Division) #250.

“Synthesis and In Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol-3-Kinase”, L.C.Creemer, H.A.Kirst, C.J.Vlahos, R.M.Schultz, 25th National Medicinal Chemistry Symposium, University of Michigan, Ann Arbor, Michigan, June 18-22, 1996, Abstract #3.

“Chemistry and Biology of the Spinosyns: Components of Spinosad (Tracer), The First Entry into DowElanco’s Naturalyte Class of Insect Control Products”, T.C.Sparks, H.A.Kirst, J.S.Mynderse, G.D.Thompson, J.R.Turner, O.K.Jantz, M.B.Hertlein, L.L.Larson, P.Baker, M.C.Broughton, J.D.Busacca, L.C.Creemer, M.L.Huber, J.W.Martin, W.Nakatsukasa, J.W.Paschal, T.V.Worden, Beltwide Cotton Production Conference, Nashville, Tennessee, January 9-12, 1996, Abstract #(none).

“Chemistry and Biology of the Spinosyns: A New Class of Naturally Derived Insect Control Agents”, H.A.Kirst, T.C.Sparks, J.S.Mynderse, G.D.Thompson, J.R.Turner, O.K.Jantz, M.B.Hertlein, L.L.Larson, M.C.Broughton, J.D.Busacca, L.C.Creemer, M.L.Huber, J.W.Martin, W.M.Nakatsukasa, J.W.Paschal, T.V.Worden, 210th American Chemical Society National Meeting, Chicago, Illinois, August 20-24, 1995, Abstract (Agro-chemical Division) #61.

“The Synthesis of the Pseudoaglycones and Aglycones of Spinosyn A and Spinosyn D (Formerly A83543A and A83543D) and Their In Vivo Activity Against Tobacco Budworm”, L.C.Creemer, H.A.Kirst, T.V.Worden, CU-Hauser Symposium in Natural Products Chemistry: Chemistry and Bioactivity, Colorado University, Boulder, Colorado, May 24-26, 1995, Abstract #(none).

“Elucidation of the Structure of the Spiroketal-Macrolide Antibiotic A82548A”, H.A.Kirst, L.C.Creemer, S.H.Larsen, J.L.Occolowitz, J.W.Paschal, J.L.R.Steiner, E.Lobkovsky, J.Clardy, fourth International Conference on Biotechnology of Microbial Products, Oiso, Japan, April 23-26, 1995, Abstract #P1-7.

“Synthesis, Antimicrobial Activity, and Fluorine-NMR Spectroscopy of Fluorinated Derivatives of Erythromycin and Tylosin for Non-Invasive In Vivo Studies of Macrolide Pharmacokinetics and Distribution by 19 F-NMR”, L.C.Creemer, H.A.Kirst, J.B.Campbell, A.G.Webb, 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Florida, October 4-7, 1994, Abstract #F170.

“The Synthesis and Biological Activity of Cinoxacinoyl-Novenamine, A Novel Novobiocin-Cinoxacin Hybrid”, L.C.Creemer, D.L.Letourneau, fourth International Conference on Chemical Synthesis of Antibiotics and Related Microbial Products, Nashville, Indiana, September 11-16, 1994, Abstract #6.

“Determination of the Inherent Antimicrobial Activity of Dirithromycin by Measuring Cell-Free Inhibition of Protein Synthesis”, H.A.Kirst, D.A.Preston, W.E.Alborn Jr.,L.C.Creemer, second International Conference on Macrolides, Azalides and Streptogramins, Venice, Italy, January 19-22, 1994.

“Selective Transformations of 14- and 16-Membered Macrolide Compounds”, H.A.Kirst, L.C.Creemer, J.P.Leeds, J.G.Martynow, 206th American Chemical Society National Meeting, Chicago, Illinois, August 22-27, 1993, Abstract (Organic Division) #45.

LAWRENCE C. CREEMER lccreemer@gmail.com PAGE THREE

“Inhibition of Protein Synthesis as a Measure of the Inherent Antibacterial Activity of Dirithromycin”, H.A.Kirst, D.A.Preston, W.E.Alborn Jr., L.C.Creemer, 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana, October 17-20, 1993; Abstract #212.

"Synthesis and Epimerization of Dirithromycin and Related Oxazines", H.A.Kirst, J.M.Greene, L.C.Creemer, J.G.Amos, R.L.Clemens, K.A.Sullivan, J.W.Paschal, F.T.Counter, first International Conference on Macrolides, Azalides and Streptogramins, Santa Fe, New Mexico, January 22-25, 1992; Abstract #105.

"Synthesis, Characterization, Epimerization and Antimicrobial Evaluation of Epidirithromycin and Related 9-N-11-O-Oxazines of 9-(S)-Erythromycylamine", H.A.Kirst, J.M.Greene, J.G.Amos, R.L.Clemens, K.A. Sullivan, L.C.Creemer, J.W.Paschal, F.T.Counter , 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, California, October 11-14, 1992; Abstract #1365.

"Biosynthesis of the Macrolide Insecticidal Compound A83543 by Saccharopolyspora Spinosa", M.C. Broughton, M.L.B. Huber, L.C.Creemer, H.A.Kirst, J.R.Turner, 90th Annual

Meeting of the American Society for Microbiology, Dallas, Texas, May 5-9, 1991; Abstract #K58.

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